| File
name
|
MoIHC86aMeddis.[ch]
|
| Description
|
This
module is the Meddis 86a inner hair cell (IHC) synapse module. It is the same
as the Meddis 86 IHC model, but using an exponential permeability function. It
requires an IHC receptor potential module as input. It outputs spike
probabilities.
|
| Example
parameter file format
|
10.0 Max. no. of transmitter packets in free pool. 5.05 Replenishment rate (units per second). 2500.0 Loss rate (units per second). 66.31 Reprocessing rate (units per second). 6580.0 Recovery rate (units per second). 20000.0 Firing rate (spikes per second). 900.0 Permeability constant, h. 0.5 Permeability constant, z. |
| Test
program directory
|
Tests/Models/Transduction/Hair_Cell,
Tests/SSPrograms
|
| Syntax
|
BOOLN RunModel_IHC_Meddis86a(EarObjectPtr
data);
|
| Returns
|
TRUE
if the process is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetFiringRate_IHC_Meddis86a(double
theSetFiringRate);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetLossRate_IHC_Meddis86a(double
theLossRate);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetMaxFreePool_IHC_Meddis86a(double
theMaxFreePool);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetPars_IHC_Meddis86a(double y, double
l, double x, double r, double M, double h,
double z, double h2);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetPermeabilityPH_IHC_Meddis86a(double
thePermeabilityPH);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetPermeabilityPZ_IHC_Meddis86a(double
thePermeabilityPZ);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetReplenishRate_IHC_Meddis86a(double
theReplenishRate);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetReprocessRate_IHC_Meddis86a(double
theReprocessRate);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
| Syntax
|
BOOLN SetRecoveryRate_IHC_Meddis86a(double
theRecoveryRate);
|
| Returns
|
TRUE
if the function is successful, otherwise it returns FALSE.
|
# # Main Parameter file # output.dat Name of output file. # Module specifications. #Par. file Name Description #--------- ----- ------------- PTone1.par PureTone Stimulus generation paradigm. GPig1ChinPE.par PreEmphasis_BandPass Outer-/middler-ear filter model. DRNL18k.par BasilarM_DRNL basilar membrane filter model. ShammaRP1.par IHCRP_Shamma IHC receptor potential model. Medd86aM.par IHC_Meddis86a Inner hair cell (IHC) model. SpikeGn1.par null Auditory nerve spike generation. Dendrite3.par null Dendritic filtering. MG0Stellate.par null Neural cell model. Histogm1.par Histogram module parameter file. # Miscellaneous parameters 1 Number of model runs. 125.0 Initial stimulus frequency (Hz). 10000.0 Final stimulus frequency (Hz). 10 Number of frequency readings readings. 2.5e-3 Ramp up rise time for signal (s).
See figure [89] on page 174.
# # Main Parameter file # output.dat Name of output file. # Module specifications. #Par. file Name Description #--------- ----- ------------- PTone1.par PureTone Stimulus generation paradigm. GPig1ChinPE.par PreEmphasis_BandPass Outer-/middler-ear filter model. DRNL1k.par BasilarM_DRNL basilar membrane filter model. ShammaRP1.par IHCRP_Shamma IHC receptor potential model. Medd86aM.par IHC_Meddis86a Inner hair cell (IHC) model. SpikeGn1.par null Auditory nerve spike generation. Dendrite3.par null Dendritic filtering. MG0Stellate.par null Neural cell model. Histogm1.par Histogram module parameter file. # Miscellaneous parameters 10 Number of analysis readings. 1 Number of model runs. 1000.0 Stimulus frequency (Hz). -40.0 Initial stimulus signal intensity (dB SPL). 10.0 Intensity increment for successive readings (dB). 2.5e-3 Ramp up rise time for signal (s).
Figure [107] Firing characteristics for the Meddis `86a AN model in relation to changing intensity.
See also figure [91] on page 175.
# # Main Parameter file # output.dat Name of output file. # Module specifications. #Par. file Name Description #--------- ----- ------------- PTone4.par PureTone Stimulus generation paradigm. GPig1ChinPE.par PreEmphasis_BandPass Outer-/middler-ear filter model. DRNL18k.par BasilarM_DRNL basilar membrane filter model. ShammaRP1.par IHCRP_Shamma IHC receptor potential model. Medd86aM.par IHC_Meddis86a Inner hair cell (IHC) model. SpikeGn1.par null Auditory nerve spike generation. Dendrite3.par null Dendritic filtering. MG0Stellate.par null Neural cell model. Histogm2.par Histogram module parameter file. FindBin1.par Find maximum bin values analysis module parameter file. # Miscellaneous parameters 10 Number of analysis readings. 1 Number of model runs. 1 Number of fibre responses (IHC -> AnN repeats). 0.0 Initial stimulus signal intensity (dB SPL). 10 Intensity increment for successive readings (dB). 2.5e-3 Ramp up rise time for signal (s).
Figure [108] Rate-intensity functions for the Meddis `86a AN model.
|
Figure [109] Rate-intensity functions for the Meddis `86a AN model. Note
that the main parameter file was changed to produce this diagram: the
"ANSpikeGen_Simple" module was put in (using the "SpikeGn2.par" module
parameter file, the "Histogm2.par" module parameter file was replaced by
"Histogm4.par" and the number of model runs was set to 200.
|
See also figure [94] on page 177.
# # SimulationSpec main parameter file. # output.dat Output file. SimSpecs/IHC/Medd86aHist.sim Simulation Specification file. # Misc. parameters. 1 Number of repeat runs.
Figure [110] Post stimulus time histogram (PSTH) for the Meddis `86a AN model.
Example: Tests/Models/Transduction/Hair_Cell/TwoCAdapt.c
# # Main Parameter file # output.dat Name of output file. # Module specifications. #Par. file Name Description #--------- ----- ------------- PTone3.par PureTone Stimulus generation paradigm. GPig1ChinPE.par PreEmphasis_BandPass Outer-/middler-ear filter model. DRNL1k.par BasilarM_DRNL basilar membrane filter model. ShammaRP1.par IHCRP_Shamma IHC receptor potential model. Medd86aM.par IHC_Meddis86a Inner hair cell (IHC) model. SpikeGn1.par null Auditory nerve spike generation. Dendrite3.par null Dendritic filtering. MG0Stellate.par null Neural cell model. Histogm1.par Histogram module parameter file. # Miscellaneous parameters 9 Number of analysis readings. 1 Number of model runs. 1 Number of fibre responses (IHC -> AnN repeats). 20.0 Initial stimulus signal intensity (dB SPL). 10.0 Intensity increment for successive readings (dB). 2.5e-3 Ramp up rise time for signal (s). 3.0e-3 Short-term time, T1 for approximation calculation. (s). 40.0e-3 Short-term period for approximation calculation (s). 2.0e-3 Rapid adapt period for approximation calculation.
Figure [111] Two-component adaptation characteristics for the Meddis `86a AN
model.
Comment
At the time of writing, the PC version encounters an error calculating the nineth analysis reading for this test program (with an "exp overflow error"). No attempt has yet been made to address this problem, as the model is still in development. Also the problem did not occur in the Macintosh and UNIX testing. There is no problem with the previous calculated readings when the program is run, calculating only the first eight readings.
# # Main Parameter file # output.dat Name of output file. # Module specifications. #Par. file Name Description #--------- ----- ------------- MPTone1.par PureTone_Multi Stimulus generation paradigm. GPig1ChinPE.par PreEmphasis_BandPass Outer-/middler-ear filter model. DRNL8k.par BasilarM_DRNL basilar membrane filter model. ShammaRP1.par IHCRP_Shamma IHC receptor potential model. Medd86aM.par IHC_Meddis86a Inner hair cell (IHC) model. SpikeGn1.par null Auditory nerve spike generation. Dendrite3.par null Dendritic filtering. MG0Stellate.par null Neural cell model. Histogm1.par Histogram module parameter file. # Miscellaneous parameters 20 Number of test frequencies. 1 Number of model runs. 2000.0 Lowest test frequency (Hz). 15170.0 Highest test frequency (Hz). 80.0 Test pure tone initial intensity (dB SPL). 0.0 Final test stimulus Intensity step (dB SPL). 10.0 Test stimulus intensity decrement (dB). 2.5e-3 Ramp up rise time for signal (s).
Figure [112] Two-tone suppression characteristics for the Meddis `86a AN model.